CRYO-S® Painless — Advanced Targeted Neurocryoanalgesia System
1. Product Overview & Engineering Specifications Cards
100% of all official specifications certified by Metrum Cryoflex Sp. z o.o., Warsaw, Poland.
Product & Regulatory Overview
Gas Supply & Thermodynamics
Electrical, Hardware & RFID
2.5 Built-in Diagnostic Neurostimulator Subsystem
Sensory Frequencies
50 Hz, 100 Hz, 150 Hz, 200 Hz
Maps precise sensory nerve boundariesMotor Frequencies
1 Hz and 2 Hz
Verifies proximity to motor nerves to avoid freezing0 – 10 mA Current
Impulse Width: 0.1 to 5.0 ms
Includes dedicated sterile grounding pad3. Key Features & Engineering Technology
Comprehensive technology suite from Metrum Cryoflex Poland designed for pain management specialists, orthopedists, and neurosurgeons.
RFID Smart Probe Recognition
Electronic communication between probe and unit automatically identifies probe type, auto-configures pressure, and eliminates manual setup errors.
Built-in Diagnostic Neurostimulator
Precisely locates sensory (50–200 Hz) and motor (1–2 Hz) nerves before freezing, preventing accidental motor nerve damage.
Touchscreen Microprocessor Control
Displays probe temperature, cylinder pressure, gas flow rate, and countdown timer live. Minimal operator input: set time and press start.
Dual Gas Compatibility (CO₂ & N₂O)
Operates on both Carbon Dioxide (−78°C) and Nitrous Oxide (−89°C). A single 10-litre cylinder serves approximately 60 procedures.
Dual-Mode Foot Switch Control
Enables hands-free probe mode selection, cleaning cycle activation, and freeze/thaw cycle control while maintaining complete sterility.
Auto Service & Self-Diagnosis
Automatically detects reduced gas flow or probe blockage and activates service mode to ensure uninterrupted operating room performance.
Voice Communication Guidance
Real-time voice guidance provides audio confirmation of probe status, freeze cycles, and system alerts without looking at console.
Reversible Axonotmesis Safety
Freezes nerve axon while keeping epineurium sheath intact. Axon regenerates naturally in 1–3 months, preventing permanent neuroma.
4. Clinical Applications — Specialty Department Cards
Comprehensive list of target pain procedures across surgical and clinical specialties.
Pain Management Physicians
- • Chronic neuropathic pain & CRPS
- • Lumbar / cervical facet joint syndrome
- • Sacroiliac joint pain
- • Phantom limb pain & postherpetic neuralgia
- • Occipital headaches
Anesthesiologists
- • Post-thoracotomy intercostal pain
- • Post-mastectomy & chest wall pain
- • Rib fracture pain management
- • Opioid-sparing post-op protocols
- • Pre-operative nerve preparation
Orthopedic Surgeons
- • Pre / post knee arthroplasty (TKR) pain
- • Shoulder arthroplasty pain
- • Complex Regional Pain Syndrome (CRPS)
- • Sacroiliac joint pain
- • Musculoskeletal post-surgical pain
Neurosurgeons
- • Trigeminal neuralgia (Tic Douloureux)
- • Occipital neuralgia
- • Glossopharyngeal neuralgia
- • Facial & cranial nerve pain
- • Post-craniotomy nerve pain
Spine Surgeons
- • Lumbar facet joint syndrome
- • Cervical facet pain
- • Sacroiliac joint dysfunction
- • Post-laminectomy pain syndrome
- • Radiculopathy — L4 / L5 / S1
Interventional Radiologists
- • USG / CT-guided percutaneous cryoneurolysis
- • Nerve root & plexus ablation
- • Sympathetic nerve blocks
- • Tumour-adjacent nerve pain
- • Fluoroscopic-guided facet nerve blocks
Oncology Surgeons
- • Tumour nerve compression pain
- • Post-oncology surgery pain management
- • Brachial / lumbar plexopathy
- • Metastatic bone & nerve pain
- • Palliative care pain control
5. Clinical Benefits & Performance Outcomes Cards
Key clinical benefits documented in international medical studies and trial published data.
No Opioid Dependency
Completely drug-free pain management — no systemic side effects, zero addiction risk.
Minimally Invasive
Percutaneous procedure under local anaesthesia — no general anaesthesia required.
OPD / Day-Care Procedure
15–30 minutes duration. Same-day patient discharge. No overnight hospital stay.
100% Reversible Freezing
Nerve regenerates naturally in 1–3 months. No permanent nerve destruction.
Safe to Repeat
No scar tissue formation. The procedure can be safely repeated as needed.
Long-Lasting Pain Relief
Single application provides sustained pain relief from 6 months up to 2 years.
85% Pain Reduction Rate
85% Pain Reduction Rate — Clinically documented in post-thoracotomy patients.
Up to 70% Opioid Reduction
Up to 70% Opioid Reduction — Demonstrated in controlled post-op studies.
6. Regulatory Certifications & AIIMS Endorsement Cards
Certified according to European Medical Device Directives and international quality standards.
CE 2274 Marked
TÜV NORD Notified Body No. 2274
PN-EN ISO 13485:2016
Certificate AC090 MD/QMS/0275/2025
IAF & PCA Accreditations
International Accreditation Forum & Polish Centre
AIIMS New Delhi Evaluation
Formally evaluated for hospital procurement by AIIMS New Delhi for Cryoanalgesia Generator.
7. Standard Accessories & Consumables Catalog Cards
Complete accessory kit supplied with every CRYO-S® Painless generator unit.
RFID Cryoprobes
Straight, angled, and specialty probes with integrated RFID auto-recognition chip.
Single-Use Grounding Pad
Dedicated sterile grounding pad included for diagnostic neurostimulation.
Dual-Function Foot Switch
Hands-free control of mode selection, cleaning, and freeze cycles in sterile field.
Gas Cylinder Connector
Medical-grade valve connector compatible with standard CO₂ and N₂O cylinders.
8. Supplied & Supported by PrimeBridge Health
Complete post-sales service, CDSCO regulatory handling, and clinical training across India.
Direct Factory Import
Imported directly from Metrum Cryoflex, Warsaw — authenticated devices, no intermediaries.
On-Site Clinical Training
Full team training, live case demonstrations, and procedure certification at your facility.
After-Sales Service
Hyderabad-based service team. Fast spare parts supply. Full warranty coverage.
Regulatory & Demos
Complete CDSCO import documents, CE certificates, and live hospital demo arrangements.
Common Questions
No. Cryoneurolysis selectively disrupts nerve axons (Axonotmesis) while leaving the outer myelin sheath and epineurium intact. Nerve axons fully regenerate over 1 to 3 months, restoring normal sensation once pain resolves.
Before applying sub-zero freezing, the built-in neurostimulator passes low-frequency currents (1–2 Hz for motor, 50–200 Hz for sensory) through the probe tip. If a muscle twitches, the surgeon knows a motor nerve is near and adjusts probe position safely.
CRYO-S Painless works with both CO₂ (−78°C) and N₂O (−89°C). A standard 10-litre gas cylinder yields approximately 60 complete pain procedures.